Material Matters 6.3
نویسنده
چکیده
The ability for synthetic polymers to degrade in a controlled manner was developed for environmental reasons in the late 1960s. Interest in utilizing biodegradable polymers for biomedical applications rapidly followed and research focused on designing novel materials has continued to grow. Biodegradable polymers can be tailored for controlled degradation through numerous functional groups including esters, amides, anhydrides, and others. Among these, polyesters synthesized from lactide (1) and glycolide (2), shown in Figure 1, are of particular interest because they are well tolerated in biological systems and display distinct tunable physicochemical and mechanical properties. Synthetically, poly(glycolide) (PGA) (3) and poly(lactide) (PLA) (4) are typically prepared via ring-opening polymerization of lactide and glycolide, respectively. Their degradation products are predominantly glycolic acid (5) and lactic acid (6), respectively.
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